Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
N. Salzman,D. Ghosh,2 Authors,C. Bevins
2003 · DOI: 10.1038/nature01520
Nature · 795 Citations
TLDR
Support is provided for a critical in vivo role of epithelial-derived defensins in mammalian host defence by showing that HD-5 expression in these mice is specific to Paneth cells and reflects endogenous enteric defensin gene expression.