Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses.
Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses.
F. S. Saal,B. Timms,7 Authors,W. Welshons
1997 · DOI: 10.1073/PNAS.94.5.2056
Proceedings of the National Academy of Sciences of the United States of America · 743 Citations
TLDR
It is suggested that a small increase in estrogen may modulate the action of androgen in regulating prostate differentiation, resulting in a permanent increase in prostatic androgen receptors and prostate size.