Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype.
Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype.
J. Frasor,Jeanne M. Danes,3 Authors,B. Katzenellenbogen
2003 · DOI: 10.1210/EN.2003-0567
Endocrinology · 846 Citations
TLDR
The use of global gene expression profiling by Affymetrix GeneChip microarray analysis to identify patterns and time courses of genes that are either stimulated or inhibited by estradiol (E2) in estrogen receptor (ER)-positive MCF-7 human breast cancer cells is highlighted.