Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
S. Korsmeyer,M. Wei,4 Authors,P. Schlesinger
2000 · DOI: 10.1038/sj.cdd.4400783
Cell Death and Differentiation · 1,074 Citations
TLDR
An activation cascade of pro-apoptotic proteins from BID to BAK or BAX integrates the pathway from surface death receptors to the irreversible efflux of cytochrome c.