Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
Kole T. Roybal,Levi J. Rupp,4 Authors,W. Lim
2016 · DOI: 10.1016/j.cell.2016.01.011
Cell · 839 Citations
TLDR
A combinatorially activated T cell circuit in which a synthetic Notch receptor for one antigen induces the expression of a CAR for a second antigen opens the door to immune recognition of a wider range of tumors.