Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni
Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni
Zuowei Wu,Balamurugan Periaswamy,7 Authors,Qijing Zhang
2016 · DOI: 10.1073/pnas.1605869113
Proceedings of the National Academy of Sciences of the United States of America · 55 Citations
TLDR
This results identify a key virulence factor in Campylobacter and a potential target for the control of this zoonotic pathogen, and provides general, unbiased experimental and computational approaches that are broadly applicable for efficient elucidation of disease-causing mutations in bacterial pathogens.