Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo.
Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo.
Rukhsana Aslam,E. Speck,7 Authors,J. Semple
2006 · DOI: 10.1182/BLOOD-2005-06-2202
Blood · 514 Citations
TLDR
The results suggest that platelets express various TLRs and that the functional significance of one of these, TLR4, appears to be a role in the modulation of LPS-induced thrombocytopenia and TNF-alpha production, and implicates platelets as important mediators of innate immune responses against invading microorganisms.