Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
Katarina Wolf,Mariska te Lindert,7 Authors,P. Friedl
2013 · DOI: 10.1083/jcb.201210152
Journal of Cell Biology · 1,308 Citations
TLDR
The physical limits of cell migration in dense porous environments are dependent upon the available space and the deformability of the nucleus and are modulated by matrix metalloproteinases, integrins and actomyosin function.
Abstract
The physical limits of cell migration in dense porous environments are dependent upon the available space and the deformability of the nucleus and are modulated by matrix metalloproteinases, integrins and actomyosin function.