Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
A. Kuhn,M. Diken,7 Authors,U. Şahin
2010 · DOI: 10.1038/gt.2010.52
Gene Therapy · 217 Citations
TLDR
5′ mRNA cap analogs are established as yet another module for tuning immunopharmacological properties of recombinant antigen-encoding RNA for vaccination purposes by analyzing the effect of different synthetic 5′ mRNAcap analogs on the kinetics of the encoded protein.