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Pentagalloyl glucose reverses chemoresistance in triple-negative breast cancer via EMT inhibition and miRNA modulation.

Jiraporn Kantapan,Phattarawadee Innuan,3 Authors,Nathupakorn Dechsupa

2025 · DOI: 10.1016/j.biopha.2025.118572
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TLDR

PGG reverses DOX resistance in TNBC cells through multiple mechanisms involving EMT inhibition, MDR suppression, and restoration of miR-200c-3p expression, suggesting that PGG holds promise as an adjuvant therapeutic agent for managing multidrug-resistant TNBC.

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