Paroxetine-induced transient apoptosis with delayed neurogenesis induces brain remodeling in developing zebrafish

It is demonstrated that early exposure of zebrafish embryos to paroxetine retards neurogenesis in the optic tectum and the telencephalon that includes a region corresponding to the mammalian amygdala, suggesting a biological mechanism underlying early exposure to paroxetine, a risk factor associated with the pathogenesis of ASD.