Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells.
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells.
M. Bachem,Marion Schünemann,6 Authors,G. Adler
2005 · DOI: 10.1053/J.GASTRO.2004.12.036
Gastroenterology · 648 Citations
TLDR
Pancreatic stellate cells strongly support tumor growth in the nude mouse model and the increased deposition of connective tissue in pancreatic carcinoma is the result of a paracrine stimulation of pancreatic stllate cells by carcinoma cells.