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OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery

Zhongyue Zhang,Zijie Qiu,23 Authors,Shuangjia Zheng

2026 · DOI: 10.1101/2025.06.03.657658
bioRxiv · 17 Citations

TLDR

OriGene consistently outperforms human experts, leading research agents, and state-of-the-art large language models in accuracy, recall, and robustness, particularly under conditions of data sparsity or noise, demonstrating its potential as a scalable and adaptive platform for AI-driven discovery of mechanistically grounded therapeutic targets.