On the Dependency of Cellular Protein Levels on mRNA Abundance.
On the Dependency of Cellular Protein Levels on mRNA Abundance.
Yansheng Liu,A. Beyer,R. Aebersold
2016 · DOI: 10.1016/j.cell.2016.03.014
Cell · 2,823 Citations
TLDR
It is concluded that transcript levels by themselves are not sufficient to predict protein levels in many scenarios and to thus explain genotype-phenotype relationships and that high-quality data quantifying different levels of gene expression are indispensable for the complete understanding of biological processes.
