Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model
Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model
K. Murai,Qiuhao Qu,6 Authors,Yanhong Shi
2014 · DOI: 10.1073/pnas.1406779111
Proceedings of the National Academy of Sciences of the United States of America · 58 Citations
TLDR
A transgenic mouse model that expresses TLX under the control of the promoter of nestin, a neural precursor marker, suggests a strong association between hippocampal neurogenesis and cognition, as well as significant contributions of TLX to hippocampal Neurogenesis, learning, and memory.