Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K. Jha,S. C. Huang,10 Authors,M. Artyomov
2015 · DOI: 10.1016/j.immuni.2015.02.005
Immunity · 1,762 Citations
TLDR
An integrated high-throughput transcriptional-metabolic profiling and analysis pipeline provides a highly integrated picture of the physiological modules supporting macrophage polarization, identifying potential pharmacologic control points for both macrophages.