Neofunctionalization of Androgen Receptor by Gain-of-Function Mutations in Teleost Fish Lineage.
Neofunctionalization of Androgen Receptor by Gain-of-Function Mutations in Teleost Fish Lineage.
Y. Ogino,Shigehiro Kuraku,7 Authors,T. Iguchi
2016 · DOI: 10.1093/molbev/msv218
Molecular biology and evolution · 50 Citations
TLDR
Findings together indicate that the substitutions generating a new functionality of teleost ARα were fixed in teleost genome after the divergence of the Elopomorpha lineage, and provide a molecular explanation for an adaptation process leading to generation of the hyperactive AR subtype after TSGD.