Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
R. Chemelli,Jon T. Willie,12 Authors,M. Yanagisawa
1999 · DOI: 10.1016/S0092-8674(00)81973-X
Cell · 3,031 Citations
TLDR
It is proposed that orexin regulates sleep/wakefulness states, and that Orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation.