Monoamine neurocircuitry in depression and strategies for new treatments
Monoamine neurocircuitry in depression and strategies for new treatments
M. Hamon,P. Blier
2013 · DOI: 10.1016/j.pnpbp.2013.04.009
Progress in Neuro-psychopharmacology and Biological Psychiatry · 558 Citations
TLDR
Data provided a rationale for the design of new, multimodal, therapeutic strategies involving drugs acting not only at the "historical" targets such as the 5-HT and/or the NE transporter, but also at other molecular targets to improve their efficacy and their tolerability.