Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery.
Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery.
Q. Gan,Tao Wang,C. Cochrane,P. McCarron
2005 · DOI: 10.1016/J.COLSURFB.2005.06.001
Colloids and Surfaces B: Biointerfaces · 897 Citations
TLDR
This study demonstrates that systematic design and modulation of the surface charge and particle size of chitosan-TPP nanoparticles can be readily achieved with the right control of critical processing parameters, especially the chitOSan to TPP weight ratio.