Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies
Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies
M. Sandri,L. Coletto,P. Grumati,P. Bonaldo
2013 · DOI: 10.1242/jcs.114041
Journal of Cell Science · 175 Citations
TLDR
The current view on the role of autophagy lysosome and ubiquitin-proteasome in the pathogenesis of myopathies and muscular dystrophies is discussed, and how alteration of these degradative systems contribute to muscle wasting in inherited muscle disorders is discussed.