MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.
MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.
A. Frampton,L. Castellano,18 Authors,L. Jiao
2014 · DOI: 10.1053/j.gastro.2013.10.010
Gastroenterology · 166 Citations
TLDR
Findings indicate that miRNAs act together to promote tumor progression; therapeutic strategies might require inhibition of several miRN as well as functional miRNA-mRNA interactions that contribute to growth of PDACs.