Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer
Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer
Alexander Beatty,Lauren S. Fink,9 Authors,J. R. Peterson
2017 · DOI: 10.1158/1535-7163.MCT-17-0407
Molecular Cancer Therapeutics · 50 Citations
TLDR
Findings support the potential of targeting the glutathione biosynthetic pathway as a therapeutic strategy in TNBC and identify the non-basal-like subset as most likely to respond.