Membrane targeting by pleckstrin homology domains.
Membrane targeting by pleckstrin homology domains.
G. Cozier,J. Carlton,D. Bouyoucef,Peter J. Cullen
2004 · DOI: 10.1007/978-3-642-18805-3_3
Current Topics in Microbiology and Immunology · 95 Citations
TLDR
The structural aspects of how PH domains have evolved to bind various phosphoinositide-mediated association to plasma and internals membranes are described, and the issue of PH domains in protein:protein interactions and the allosteric regulation of their host protein is raised.