Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells.
Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells.
S. Ishihara,D. Inman,2 Authors,P. Keely
2017 · DOI: 10.1158/0008-5472.CAN-17-0569
Cancer Research · 78 Citations
TLDR
It is shown that ECM stiffness leads to mechano-signal transduction in MSC, which promotes mammary tumor growth in part through secretion of the signaling protein prosaposin, triggering enhanced proliferation and survival of mammary cancer cells.