Mechanism of Amphotericin B Resistance in Clinical Isolates of Leishmania donovani
Mechanism of Amphotericin B Resistance in Clinical Isolates of Leishmania donovani
Bidyut Purkait,Ashish Kumar,9 Authors,P. Das
2011 · DOI: 10.1128/AAC.00030-11
Antimicrobial Agents and Chemotherapy · 295 Citations
TLDR
It can be concluded that altered membrane composition, ATP-binding cassette transporters, and an upregulated thiol metabolic pathway have a role in conferring amphotericin B resistance in clinical isolates of Leishmania donovani.