Matrix elasticity directs stem cell lineage specification.
Matrix elasticity directs stem cell lineage specification.
A. Engler,A. Engler,3 Authors,D. Discher
2006 · DOI: 10.1016/J.CELL.2006.06.044
Cell · 13,172 Citations
TLDR
Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.