MANIFESTASI KLINIS DEMAM BERDARAH DENGUE (DBD)

Dengue Hemorrhagic Fever is an infectious disease caused by the dengue virus. Humans will become infected after being infected by the Aedes Aegypti mosquito that carries the DENV virus. Dengue virus consists of 4 serotypes namely DENV-1, 2, 3 and 4. Dengue virus can cause two types of infection, namely primary infection and secondary infection. Primary infection may appear as acute fever or called dengue fever which will be neutralized within seven days by the immune response. While secondary infections tend to be more severe and will result in dengue hemorrhagic fever (DHF) or dengue shock syndrome (SRD). The clinical manifestations of DHF can be classified based on the patient's clinical condition and the results of investigations. Symptomatic cases can be divided into several classifications including undifferentiated febrile illness (UF), Dengue Fever (DD), Dengue Hemorrhagic Fever (DHF), Dengue shock syndrome (SRD) and unusual dengue (UD). Clinical manifestations can impact organs and systems throughout the body. Dengue clinical manifestations vary from mild to severe. The main manifestation is the presence of plasma leakage which is described in the initial phase of light to heavy bleeding. Plasma leakage signs can also be found in multiple organs. Classification of DHF can be done based on WHO 1997 and WHO 2009. . It is important to know and understand these clinical manifestations in order to make a quick diagnosis so that DHF can be managed properly, thereby reducing morbidity and mortality.