LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells.
LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells.
M. G. Smirnova,Li Guo,J. Birchall,J. Pearson
2003 · DOI: 10.1016/S0008-8749(03)00059-5
Cellular Immunology · 219 Citations
TLDR
Goblet cells, responding to the direct stimulation of bacterial LPS by two inflammatory-related processes such as production and secretion of the gel-forming mucins and the inflammatory cytokine IL-8, can be considered as an important part of mucosal immunity and LPS- induced goblet cell mucin secretion can occur partly via IL- 8-dependent pathway.