Low levels of mutant ubiquitin are degraded by the proteasome in vivo
Low levels of mutant ubiquitin are degraded by the proteasome in vivo
P. van Tijn,M. Verhage,2 Authors,D. Fischer
2010 · DOI: 10.1002/jnr.22396
Journal of Neuroscience Research · 18 Citations
TLDR
It is confirmed that, in healthy brain, UBB+1 is continuously degraded and disease‐related UBB-1 accumulation serves as an endogenous marker for proteasomal dysfunction, and this novel transgenic mouse line can give more insight into the intrinsic properties of U BB+1 and its role in neurodegenerative disease.