Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms
Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms
S. Andrisse,S. Childress,7 Authors,Sheng Wu
2017 · DOI: 10.1210/en.2016-1553
Endocrinology · 41 Citations
TLDR
A phenotype of impaired glucose tolerance and disrupted glucose metabolism is presented in a lean hyperandrogenemia model (low-dose DHT) and data is provided to support 2 molecular mechanisms that help drive androgen-induced impaired glucose metabolism.