Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR
R. Nishiwaki‐Matsushima,T. Ohta,5 Authors,H. Fujiki
2005 · DOI: 10.1007/BF01629424
Journal of Cancer Research and Clinical Oncology · 568 Citations
TLDR
It is shown that microcystin-LR, applied below the acute toxicity level, dose-dependently increases the number and percentage area of positive foci for the placental form of glutathioneS-transferase in rat liver, which was initiated with diethylnitrosamine.