Lineage-specific CDK activity dynamics characterize early mammalian development
Lineage-specific CDK activity dynamics characterize early mammalian development
Bechara Saykali,Andy D. Tran,6 Authors,Sergio Ruiz
2025 · DOI: 10.1016/j.celrep.2025.115558
Cell Reports · 2 Citations
TLDR
It is shown that cell fate decisions in the pre-implantation embryo are not determined by the establishment of oscillatory CDK activity or overall changes in CDK activity, and the existence of conserved regulatory mechanisms in mammals is uncovered by revealing lineage-specific regulation of CDK activity in TE-like human cells.