Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.
Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.
W. Sandtner,J. Szendroedi,6 Authors,H. Todt
2004 · DOI: 10.1124/MOL.66.3
Molecular Pharmacology · 526 Citations
TLDR
It is proposed that I(US) involves a closure of the inner vestibule of the channel, and lidocaine may interfere with this pore motion by acting as a "foot in the door" in the inner vestibule.