L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats.
L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats.
M. Legrand,E. Almac,5 Authors,C. Ince
2009 · DOI: 10.1152/ajprenal.90371.2008
85 Citations
TLDR
It is demonstrated that renal I/R induces early iNOS-dependent microvascular hypoxia in disrupting the balance between microv vascular oxygen supply and Vo(2)(ren), whereas endothelial NO synthase activity is compulsory for the maintenance of this balance.