Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
A. Sottoriva,A. Sottoriva,10 Authors,Simon Tavaré
2013 · DOI: 10.1073/pnas.1219747110
Proceedings of the National Academy of Sciences of the United States of America · 1,684 Citations
TLDR
The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.