Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,F. Batliwalla,9 Authors,T. Behrens
2003 · DOI: 10.1073/pnas.0337679100
Proceedings of the National Academy of Sciences of the United States of America · 2,260 Citations
TLDR
Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.