Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.
Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.
O. Petersen,Lone Rønnov-Jessen,A. Howlett,M. Bissell
1992 · DOI: 10.1073/PNAS.89.19.9064
Proceedings of the National Academy of Sciences of the United States of America · 1,143 Citations
TLDR
It is shown that a reconstituted basement membrane (BM) can be used to culture all normal human breast epithelial cells and a subset of human breast carcinoma cells and it is proposed that the ability to sense BM appropriately and to form three-dimensional organotypic structures may be the function of a class of "suppressor" genes that are lost as cells become malignant.