Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in the guinea-pig.
Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in the guinea-pig.
T. Coccini,S. Candura,2 Authors,M. Tonini
1993 · DOI: 10.1016/0926-6917(93)90018-L
European Journal of Pharmacology · 13 Citations
TLDR
ivermectin and lindane, two neurotoxic pesticides interfering with central GABAErgic transmission, exert agonist and non-competitive antagonist properties at the enteric GABAA receptor-ionophore complex, which can thus be considered as an additional target for the action of both these compounds.