Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.
B. Savage,E. Saldívar,Z. Ruggeri
1996 · DOI: 10.1016/S0092-8674(00)80983-6
Cell · 1,286 Citations
TLDR
Two distinct mechanisms initiating the adhesion of flowing platelets to thrombogenic surfaces are identified: glycoprotein Ib alpha binding to immobilized von Willebrand factor (vWF) and activated alpha IIb beta 3.