Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes.
Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes.
M. Runnegar,Shouming Kong,Y. Zhong,Shelly C. Lu
1995 · DOI: 10.1016/S0006-2952(94)00466-8
Biochemical Pharmacology · 246 Citations
TLDR
It is likely that cytochrome P450 is involved in the metabolism of CY, and the metabolite(s) that is generated may be more toxic and/or potent in inhibiting GSH synthesis.