Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity
Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity
S. Yoshizawa,R. Matsushima,4 Authors,H. Fujiki
2005 · DOI: 10.1007/BF01637082
Journal of Cancer Research and Clinical Oncology · 402 Citations
TLDR
The hepatotoxicity of microcystins and nodularin may result from inhibition of protein phosphatases and the increase of phosphoproteins, which is similar to that of okadaic acid in the nanomolar range of concentration.