Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds.
Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds.
Nader D. Halim,B. Lipska,6 Authors,J. Kleinman
2008 · DOI: 10.1016/j.jneumeth.2007.11.017
Journal of Neuroscience Methods · 88 Citations
TLDR
The data suggest that lactate increases in postmortem human brain of patients with schizophrenia are associated with decreased pH and that these changes are possibly related to antipsychotic treatment rather than a primary metabolic abnormality in the prefrontal cortex of Patients with schizophrenia.