Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies
Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies
Chunhong Zhao,Xiaofang Li,3 Authors,M. Hou
2008 · DOI: 10.3324/haematol.12889.
Haematologica · 110 Citations
TLDR
Idiopathic thrombocytopenic purpura is a common hematologic disorder manifested by autoantibody-mediated platelet destruction and may not only damage platelets via the reticuloendothelial.
Abstract
Idiopathic thrombocytopenic purpura (ITP) is a common hematologic disorder manifested by autoantibody-mediated platelet destruction. In the majority of ITP patients, autoantibodies were found to be specific to GPIIb/IIIa or GPIb/IX.[1][1] It may not only damage platelets via the reticuloendothelial