Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
Weiling Xu,F. Kaneko,10 Authors,S. Erzurum
2004 · DOI: 10.1096/fj.04-2317fje
The FASEB Journal · 381 Citations
TLDR
Substrate availability affects NOS activity and vasodilation, implicating arginase II and alterations in arginine metabolic pathways in the pathophysiology of PAH.