In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
M. Bez,Dmitriy Sheyn,14 Authors,D. Gazit
2017 · DOI: 10.1126/scitranslmed.aal3128
Science Translational Medicine · 126 Citations
TLDR
It is demonstrated that ultrasound-mediated gene delivery to endogenous mesenchymal progenitor cells can effectively treat nonhealing bone fractures in large animals, thereby addressing a major orthopedic unmet need and offering new possibilities for clinical translation.