Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes
Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes
H. B. Nielsen,Mathieu Almeida,96 Authors,S. Ehrlich
2014 · DOI: 10.1038/nbt.2939
Nature Biotechnology · 1,051 Citations
TLDR
This work presents a method, based on binning co-abundant genes across a series of metagenomic samples, that enables comprehensive discovery of new microbial organisms, viruses and co-inherited genetic entities and aids assembly of microbial genomes without the need for reference sequences.
