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Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

H. B. Nielsen,Mathieu Almeida,96 Authors,S. Ehrlich

2014 · DOI: 10.1038/nbt.2939
Nature Biotechnology · 1,051 Citations

TLDR

This work presents a method, based on binning co-abundant genes across a series of metagenomic samples, that enables comprehensive discovery of new microbial organisms, viruses and co-inherited genetic entities and aids assembly of microbial genomes without the need for reference sequences.