Hyperglycemia accentuates and ketonemia attenuates hypoglycemia-induced neuronal injury in the developing rat brain
Hyperglycemia accentuates and ketonemia attenuates hypoglycemia-induced neuronal injury in the developing rat brain
K. Ennis,Hannah Dotterman,Ariel B. Stein,R. Rao
2015 · DOI: 10.1038/pr.2014.146
Pediatric Research · 32 Citations
TLDR
Hyperglycemia accentuated hypoglycemia-induced neuronal injury, likely via PARP-1 overactivation, and was not neuroprotective and potentially exaggerated injury by binding to p75NTR receptor.