Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
Laura N. Vandenberg,T. Colborn,9 Authors,J. P. Myers
2012 · DOI: 10.1210/er.2011-1050
Endocrine reviews · 2,968 Citations
TLDR
It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.