hSirT1-Dependent Regulation of the PCAF-E2F1-p73 Apoptotic Pathway in Response to DNA Damage
hSirT1-Dependent Regulation of the PCAF-E2F1-p73 Apoptotic Pathway in Response to DNA Damage
N. Pediconi,F. Guerrieri,6 Authors,M. Levrero
2009 · DOI: 10.1128/MCB.00552-08
Molecular and Cellular Biology · 76 Citations
TLDR
It is shown that the hSirT1/PCAF interaction controls the E2F1/p73 apoptotic pathway and is identified as potential targets to modulate tumor cell survival and chemoresistance irrespective of p53 status.